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How injectable/oral GLP-1 medications work: Mimic the GLP-1 hormone with engineered modifications for extended duration Bind to GLP-1 receptors to enhance insulin release and reduce glucagon Slow gastric emptying by 20-50%, promoting satiety Supported by large randomized controlled trialsthe STEP trials showed 14.9% mean weight loss at 68 weeks versus 2.4% for placebo The short answer on why patches cant deliver these drugs: GLP-1 molecules are relatively large peptide chains (molecular weight 3-5 kDa) that cannot effectively penetrate the skin barrier through passive transdermal diffusion

Although both drug classes could theoretically offer neuroprotective benefits based on their mechanisms of action, RCTs have provided mixed or inconclusive results

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Cost-efficiency extends beyond the per-unit price